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ICR/Mlac-Hydro

Written by Super User. Posted in Animals

Name Mouse
Sciencetific Name Mus  musculus
Strain ICR Hydro
Source National Laboratory Animal Center established since (1992)
Coat color Albino
Biological Data  
Adult body weight 

Male 25-40 grams,Female  20-35 grams.

Average life span 2-2.5 years.
Age at mating

Male 6-8 weeks (25-40 grams) , Female 6-8 weeks (25-35 grams)

Estrous cycle  4-5 days
Duration of estrus 10 hours
Reproductive time 8-9 months
Gestation period  19-21 days
Weaning age  19-21 days (10-14 grams)
Litter size 1-14 pups (average 7)
Normal birth weight  1-1.5 grams
Post partum estrus  - NO -
Food consumption  3-6 grams /animal/day (Adult)
Water consumption 

3-8 ml/animal/day (Adult)

Nipples  10,3 Pairs on the thorax, 2 Pairs on the abdomen.
Eyes open  12 days
Incidence of Hydonephrosis 100% positive in both sex
Severity Incidence of servere hydronephrosis in both sides of kidney
Growth rate  - NO -

Husbandry

Breeding Systems

Inbred for 26 generations +. Hydronephrosis mice are maintained in brother/sister mating system.

 

Environment

                The ICR hydronephrosis mouse is housed in the controlled environment. The ventilation, temperature and humidity are controlled by HVAC (Heating, Ventilating, Air conditioning) system.  

- Temperature range at about 24 ± 2 ํC 

- Relative humidity is ranged between  55 + 10%

- Air changes per hour 10-15 ACH

- Light: and  dark cycle 12:12 hours

- Mouse is sensitive to noise so the noise level should be < 85 db.

Feed and water

           The ICR hydronephrosis mouse is fed on the commercial diet (No. CP 082) product of Perfect companion group co. Ltd. which milled according to our requested specifications. Food is provided ad libitum  in stainless steel wire- bar lid feeders. The chlorinated RO Water is used for the drinking water. 10-12 ppm chlorination make the water free from Pseudomonas aeruginosa. Drinking water is provided in bottles with sipper tubes.

Bedding

 Hard wood chips (or shaving) is used for mouse as bedding material. The same bedding is used in shipping containers. Dried bedding is packed in brown paper bags and sterilized by autoclave at 135 C for 7 minutes before used.

Equipment

The ICR hydronephrosis mice are housed in shoe box Cages  as below   

Dimensions of Enclosure (W×L×H)(centimeter)

Maximum Number Animals/Enclosure

Types of Enclosure & Description

7.5 × 11.5 × 5

6 animals/cage (or) 1 animal (lactating female)/cage

Polysulfonate cages and stainless steel cages with stainless steel wire-bar lid

 

Experimental Uses

          The ICR hydronephrosis mouse is an animal model of hydronephrosis disease in human.

Characteristic

          Hydronephrosis can be observed by a slight dissecting on the affected kidneys. The cause is still unknown. No obstruction along the urinary tract was observed. The definite cause of Hydronephrosis was unable to find yet.

In severe cases the pelvocalypso region is found highly dilated and mass tissues were lost due to the back flow pressure of urine from the bladder. The most severely affected kidneys were observed on the right kidney.