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BALB/cMlac

Written by Super User. Posted in Animals

Name BALB/cMlac
Sciencetific Name Mus  musculus
Strain BALB/cMlac
Source Central Institute of Experimental Animal; CIEAJapan (1999)
Coat color Albino
Biological Data  
Adult body weight 

Male 20-40 grams,Female  20-35 grams.

Average life span 2-3years.
Age at mating

Male 7-8 week.  (25-30 grams) , Female 6-8 week. (20-25 grams)

Estrous cycle  4-5 days
Duration of estrus 6 - 11 hours
Reproductive time 8-12 months.
Gestation period  19-22 day
Weaning age  18-22 day (10-12 grams)
Litter size 1-8 pups (average 4)
Normal birth weight  1-2 grams.
Post partum estrus 70%
Food consumption  3-6 grams /animal/day (Adult)
Water consumption 

8-10 ml/animal/day (Adult)

Growth rate

   

Husbandry

Breeding system

Breeding Systems

Two mating systems are applied in breeding BALB/cMlac mouse inbred strain. Brother-sister full-sip mating system is used to maintain the strain in foundation stock and traffic light system is used breeding for production.

Foundation Stock

One male and one female of brother-sister are paired permanently throughout their breeding life span. This system allows to record complete breeding data.

Production Stock  

                The harem system or polygamous mating system is used for production animals. One male is housed with 2-4 females and pregnant females are removed to separate cages before parturition. This method increased production of animals.

Environment

The mouse is housed in controlled environment. The ventilation, temperature and humidity are controlled by HVAC (Heating, Ventilating, Air conditioning) system.  

- Temperature ranged at about 24 ± 2 ํ

- Relative humidity range of about 55 + 10%

- Air changes per hour 10-15 ACH

- Light: dark cycle 12:12 hours

- Mouse is sensitive to noise so the noise level should be maintained at 
< 85 db.

Feed and water

           Mouse is fed on the commercial diet (No. CP 082) product of Perfect companion group co. Ltd., the animal feed manufacturer which milled according to our requested specifications. Food is provided in stainless steel wire- bar lid feeders ad libitum. The RO Water is used for the drinking water which is chlorinated at a concentration of 10-12 ppm to make it free from Pseudomonas aeruginosa. The drinking water is provided in bottles with sipper tubes.

Bedding

 Hard wood chips (or shaving) is used for mouse as bedding material. The same bedding is used in shipping containers. Dried bedding is packed in brown paper bags and sterilized by autoclave at 135 C for 7 minutes before used.

Equipment

Cages used for BALB/c mice
 

Dimensions of Enclosure (W×L×H)(centimeter)

Maximum Number Animals/Enclosure

Types of Enclosure & Description

21.3 × 36.2 × 18.5

6 animals/cage (or) 1 animal (lactating female)/cage

Polysulfonate cages with stainless steel wire-bar lid

19 × 30× 13

6 animals/cage (or) 1 animal (lactating female) / cage

Polycarbonate cages with stainless wire-bar lid

 

 

C57BL/6Mlac

Written by Super User. Posted in Animals

Name C57BL/6Mlac
Sciencetific Name Mus  musculus
Strain C57BL/6mlac
Source Central Institute of Experimental Animal; CIEAJapan (1999)
Coat color Black
Biological Data  
Adult body weight 

Male 25-40 grams,Female  20-35 grams.

Average life span 2-3years.
Age at mating

Male 8-9 weeks, Female 8-9 weeks

Estrous cycle  4-5 days
Duration of estrus 6 - 11 hours
Reproductive time 8-12 months
Gestation period  19-22 days
Weaning age  18-21 days
Litter size 1-10 pups (average 7.8)
Normal birth weight  1-2 grams
Post partum estrus  - NO -
Food consumption  3-6 grams /animal/day (Adult)
Water consumption 

8-10 ml/animal/day (Adult)

Growth rate

   Generation 25

Husbandry

Breeding Systems

Two mating systems are applied in breeding C57BL/6Mlac mouse inbred strain. Brother-sister full-sip mating system is used to maintain the strain in foundation stock and traffic light system is used breeding for production.

Foundation Stock

One male and one female of brother-sister are paired permanently throughout their breeding life span. This system allows to record complete breeding data.

Production Stock  

           The harem system or polygamous mating system is used for production animals. One male is housed with 2-4 females and pregnant females are removed to separate cages before parturition. This method increased production of animals.

Environment

The C57BL/6Mlac mouse is housed in controlled environment. The ventilation, temperature and humidity are controlled by HVAC (Heating, Ventilating, Air conditioning) system.  

- Temperature ranged at about 24 ± 2 ํ

- Relative humidity range of about 55 + 10%

- Air changes per hour 10-15 ACH

- Light: dark cycle 12:12 hours

- Mouse is sensitive to noise so the noise level should be maintained at 
< 85 db.

Feed and water

           Mouse is fed on the commercial diet (No. CP 082) product of Perfect companion group co. Ltd., the animal feed manufacturer which milled according to our requested specifications. Food is provided in stainless steel wire- bar lid feeders ad libitum. The RO Water is used for the drinking water which is chlorinated at a concentration of 10-12 ppm to make it free from Pseudomonas aeruginosa. The drinking water is provided in bottles with sipper tubes.

Bedding

 Hard wood chips (or shaving) is used for mouse as bedding material. The same bedding is used in shipping containers. Dried bedding is packed in brown paper bags and sterilized by autoclave at 135 C for 7 minutes before used.

Equipment

Cages used for C57BL/6Mlac
 

Dimensions of Enclosure (W×L×H)(centimeter)

Maximum Number Animals/Enclosure

Types of Enclosure & Description

21.3 × 36.2 × 18.5
(IVC)

6 animals/cage (or) 1 animal (lactating female)/cage

Polysulfonate cages with stainless steel wire-bar lid

19 × 30× 13
(open cge)

6 animals/cage (or) 1 animal (lactating female) / cage

Polycarbonate cages with stainless wire-bar lid

 

 

DBA/2Mlac

Written by Super User. Posted in Animals

Name DBA/2Mlac  
Sciencetific Name Mus  musculus  
Strain DBA/2Mlac  
Source Central Institute of Experimental Animal; CIEAJapan (1999)  
Coat color Dilute Brown  
Biological Data    
Adult body weight  Male 25-40 grams,Female  20-35 grams.  
Average life span 2-3years.  
Age at mating Male 8-9 weeks, Female 8-9 weeks.  
Estrous cycle  4-5 days  
Duration of estrus 6-11 hours  
Reproductive time 8-12 months  
Gestation period  19-22 days  
Weaning age  19-21 days  
Litter size 1-7 pups (average 3.25)  
Normal birth weight  1-2 grams  
Post partum estrus - No -  
Food consumption  3-6 grams /animal/day (Adult)  
Water consumption 8-10 ml/animal/day (Adult)  
Growth rate - No -  
Husbandry

Breeding Systems

Two mating systems are applied in breeding DBA/2Mlac mouse inbred strain. Brother-sister full-sip mating system is used to maintain the strain in foundation stock and traffic light system is used breeding for production.

Foundation Stock

One male and one female of brother-sister are paired permanently throughout their breeding life span. This system allows to record complete breeding data.

Production Stock  

                The harem system or polygamous mating system is used for production animals. One male is housed with 2-4 females and pregnant females are removed to separate cages before parturition. This method increased production of animals.

Environment

The mouse is housed in controlled environment. The ventilation, temperature and humidity are controlled by HVAC (Heating, Ventilating, Air conditioning) system.  

- Temperature ranged at about 24 ± 2 ํC 

- Relative humidity range of about 55 + 10%

- Air changes per hour 10-15 ACH

- Light: dark cycle 12:12 hours

- Mouse is sensitive to noise so the noise level should be maintained at 
< 85 db.

Feed and water

           Mouse is fed on the commercial diet (No. CP 082) product of Perfect companion group co. Ltd., the animal feed manufacturer which milled according to our requested specifications. Food is provided in stainless steel wire- bar lid feeders ad libitum. The RO Water is used for the drinking water which is chlorinated at a concentration of 10-12 ppm to make it free from Pseudomonas aeruginosa. The drinking water is provided in bottles with sipper tubes.

Bedding

 Hard wood chips (or shaving) is used for mouse as bedding material. The same bedding is used in shipping containers. Dried bedding is packed in brown paper bags and sterilized by autoclave at 135 C for 7 minutes before used.

Equipment

Cages used for DBA/2Mlac


Dimensions of Enclosure (W×L×H)(centimeter)


 

Maximum Number Animals/Enclosure


 

Types of Enclosure & Description

 


 

21.3 × 36.2 × 18.5
(IVC)

6 animals/cage (or) 1 animal (lactating female)/cage

Polysulfonate cages with stainless steel wire-bar lid

19 × 30× 13
(open cage)

6 animals/cage (or) 1 animal (lactating female) / cage

Polycarbonate cages with stainless wire-bar lid

 
 

Space requirment for DBA/2Mlac mouse 


Weight, g.


 

floor Area/Animal, in2


 

Height/inches


 

Under 10

6

5

Up to 15

8

5

 
Up to 25 12 5
Over 25 At least 15 5
 

 

BALB/cMlac-nu

Written by Super User. Posted in Animals

Name BALB/cMlac-nu
Sciencetific Name Mus  musculus
Strain Nude (BALB/cMlac-nu)
Source Central Institute of Experimental Animal; CIEAJapan (1999)
Coat color Albino
Biological Data  
Adult body weight 

Male 25-40 grams,Female  20-35 grams.

Average life span 2-3years.
Age at mating

Male 8-9 week, Female 8-9 week.

Estrous cycle  4-5 days
Duration of estrus 6 - 11 hours
Reproductive time 8-12 months
Gestation period  19-22 days
Weaning age  19-21 days
Litter size 1-4 pups (average 2)
Normal birth weight  1-2 grams.
Post partum estrus  - NO - 
Food consumption  3-6 grams /animal/day (Adult)
Water consumption 

8-10 ml/animal/day (Adult)

Growth rate

 - NO -    

Husbandry

Breeding system

Foundation Stock

            Brother-sister mating system is used in foundation stock to maintain BALB/c-nu mice.

            The brother-sister mating system of one nu/nu male and one nu/+ female is paired permanently through out their breeding life span. This system allows complete recording.

Production Colony

           Polygamous mating system of one nude male and 2-4 nu/+ females mating type is used for the nude intensive breeding colonies.. Pregnant females removed are separated in individual cages for parturition. Then these females are returned to male for re-mating again after the pups are weaned..

From outcomes products, nu/nu males and nu/+ females are used for further breeding purposes, nu/nu females are kept for research services, and nu/+ males are sacrificed.

Environment

The mouse is housed in controlled environment. The ventilation, temperature and humidity are controlled by HVAC (Heating, Ventilating, Air conditioning) system.  

- Temperature ranged at about 24 ± 2 ํ

- Relative humidity range of about 55 + 10%

- Air changes per hour 10-15 ACH

- Light: dark cycle 12:12 hours

- Mouse is sensitive to noise so the noise level should be maintained at 
< 85 db.

Feed and water

           Mouse is fed on the commercial diet (No. CP 082) product of Perfect companion group co. Ltd., the animal feed manufacturer which milled according to our requested specifications. Food is provided in stainless steel wire- bar lid feeders ad libitum. The RO Water is used for the drinking water which is chlorinated at a concentration of 10-12 ppm to make it free from Pseudomonas aeruginosa. The drinking water is provided in bottles with sipper tubes.

Bedding

 Hard wood chips (or shaving) is used for mouse as bedding material. The same bedding is used in shipping containers. Dried bedding is packed in brown paper bags and sterilized by autoclave at 135 C for 7 minutes before used.

Equipment

Cages used for BALB/cMlac-nu
 

Dimensions of Enclosure (W×L×H)(centimeter)

Maximum Number Animals/Enclosure

Types of Enclosure & Description

21.3 × 36.2 × 18.5
(IVC)

6 animals/cage (or) 1 animal (lactating female)/cage

Polysulfonate cages with stainless steel wire-bar lid

19 × 30× 13
(open cage)

6 animals/cage (or) 1 animal (lactating female) / cage

Polycarbonate cages with stainless wire-bar lid

 

 

C3H/HeMlac

Written by Super User. Posted in Animals

Name C3H/HeMlac
Sciencetific Name Mus  musculus
Strain C3H/HeMlac
Source Central Institute of Experimental Animal; CIEAJapan (1999)
Coat color Agouti
Biological Data  
Adult body weight 

Male 25-40 grams,Female  20-35 grams.

Average life span 2-3years.
Age at mating

Male 8-9 weeks, Female 8-9 weeks.

Estrous cycle  4-5 days
Duration of estrus 6-11 hours
Reproductive time 8-12 months
Gestation period  19-22 days
Weaning age  18-21 days
Litter size 1-6 pups (average 3.2)
Normal birth weight  1-2 grams
Post partum estrus  -NO-
Food consumption  3-6 grams /animal/day (Adult)
Water consumption 

8-10 ml/animal/day (Adult)

Growth rate

   - NO -

Husbandry

Breeding system

Breeding Systems

Two mating systems are applied in breeding C3H/HeMlac mouse inbred strain. Brother-sister full-sip mating system is used to maintain the strain in foundation stock and traffic light system is used breeding for production.

Foundation Stock

One male and one female of brother-sister are paired permanently throughout their breeding life span. This system allows to record complete breeding data.

Production Stock  

           The harem system or polygamous mating system is used for production animals. One male is housed with 2-4 females and pregnant females are removed to separate cages before parturition. This method increased production of animals.

Environment

          The mice are housed in controlled environment. The ventilation, temperature and humidity are controlled by HVAC (Heating, Ventilating, Air conditioning) system.  

- Temperature ranged at about 24 ± 2 ํC 

- Relative humidity range of about 55 + 10%

- Air changes per hour 10-15 ACH

- Light: dark cycle 12:12 hours

- Mouse is sensitive to noise so the noise level should be maintained at < 85 db.

Feed and water

           The Mlac:ICR is fed on the commercial diet (No. CP 082) product of Perfect companion group co. Ltd., the animal feed manufacturer which milled according to our requested specifications. Food is provided in stainless steel wire- bar lid feeders ad libitum. The RO Water is used for the drinking water which is chlorinated at a concentration of 10-12 ppm to make it free from Pseudomonas aeruginosa. The drinking water is provided in bottles with sipper tubes.

Bedding

 Hard wood chips (or shaving) is used for mouse as bedding material. The same bedding is used in shipping containers. Dried bedding is packed in brown paper bags and sterilized by autoclave at 135 ํC for 7 minutes before used.

Equipment

Cages used for C3H/HeMlac
 

Dimensions of Enclosure (W×L×H)(centimeter)

Maximum Number Animals/Enclosure

Types of Enclosure & Description

21.3 x 36.2 x 18.5
(IVC)

6 animals/cage (or) 1 animal (lactating female)/cage

Polysulfonate cages with stainless steel wire-bar lid

19 × 30× 13
(open cage)

6 animals/cage (or) 1 animal (lactating female) / cage

Polycarbonate cages with stainless wire-bar lid

 

 

ICR/Mlac-Hydro

Written by Super User. Posted in Animals

Name Mouse
Sciencetific Name Mus  musculus
Strain ICR Hydro
Source National Laboratory Animal Center established since (1992)
Coat color Albino
Biological Data  
Adult body weight 

Male 25-40 grams,Female  20-35 grams.

Average life span 2-2.5 years.
Age at mating

Male 6-8 weeks (25-40 grams) , Female 6-8 weeks (25-35 grams)

Estrous cycle  4-5 days
Duration of estrus 10 hours
Reproductive time 8-9 months
Gestation period  19-21 days
Weaning age  19-21 days (10-14 grams)
Litter size 1-14 pups (average 7)
Normal birth weight  1-1.5 grams
Post partum estrus  - NO -
Food consumption  3-6 grams /animal/day (Adult)
Water consumption 

3-8 ml/animal/day (Adult)

Nipples  10,3 Pairs on the thorax, 2 Pairs on the abdomen.
Eyes open  12 days
Incidence of Hydonephrosis 100% positive in both sex
Severity Incidence of servere hydronephrosis in both sides of kidney
Growth rate  - NO -

Husbandry

Breeding Systems

Inbred for 26 generations +. Hydronephrosis mice are maintained in brother/sister mating system.

 

Environment

                The ICR hydronephrosis mouse is housed in the controlled environment. The ventilation, temperature and humidity are controlled by HVAC (Heating, Ventilating, Air conditioning) system.  

- Temperature range at about 24 ± 2 ํC 

- Relative humidity is ranged between  55 + 10%

- Air changes per hour 10-15 ACH

- Light: and  dark cycle 12:12 hours

- Mouse is sensitive to noise so the noise level should be < 85 db.

Feed and water

           The ICR hydronephrosis mouse is fed on the commercial diet (No. CP 082) product of Perfect companion group co. Ltd. which milled according to our requested specifications. Food is provided ad libitum  in stainless steel wire- bar lid feeders. The chlorinated RO Water is used for the drinking water. 10-12 ppm chlorination make the water free from Pseudomonas aeruginosa. Drinking water is provided in bottles with sipper tubes.

Bedding

 Hard wood chips (or shaving) is used for mouse as bedding material. The same bedding is used in shipping containers. Dried bedding is packed in brown paper bags and sterilized by autoclave at 135 C for 7 minutes before used.

Equipment

The ICR hydronephrosis mice are housed in shoe box Cages  as below   

Dimensions of Enclosure (W×L×H)(centimeter)

Maximum Number Animals/Enclosure

Types of Enclosure & Description

7.5 × 11.5 × 5

6 animals/cage (or) 1 animal (lactating female)/cage

Polysulfonate cages and stainless steel cages with stainless steel wire-bar lid

 

Experimental Uses

          The ICR hydronephrosis mouse is an animal model of hydronephrosis disease in human.

Characteristic

          Hydronephrosis can be observed by a slight dissecting on the affected kidneys. The cause is still unknown. No obstruction along the urinary tract was observed. The definite cause of Hydronephrosis was unable to find yet.

In severe cases the pelvocalypso region is found highly dilated and mass tissues were lost due to the back flow pressure of urine from the bladder. The most severely affected kidneys were observed on the right kidney.